ABSTRACT
Objective To assess the clinical value of transvaginal ultrasonic hysterography in diagnoio of intrauterine diseases. Methods Two-hundred and ninety-eight patients with transvaginal ultrasonographically diagnosed intrauterine diseases were enrolled in this study. All the patients underwent selective operation of ultrasonic hysterography and hysteroscopy. The results before and after ultrasonic hysterography were compared with those of hysteroscopy and pathology. Results Among 298 patients, 221 were diagnosed pathologically, while 198 were diagnosed with ultrasonic hysterography and 206 with hysteroscopy. The diagnostic coincidence of transvaginal ultrasonic hysterography, transvaginal ultrasound and hysteroscopy was 89.59%, 74.16% and 93.21%, respectively. Conclusion The accuracy of ultrasonic hysterography and hysteroscopy in diagnosis of intrauterine diseases is in coincidence. Ultrasonic hysterography is simple and convenient, worthy of clinical application.in gynecology.
ABSTRACT
Irritable Bowel Syndrome(IBS) is a common disease of intestinal disorder.It is characterized by chronic or recurrent abdominal pain or discomfort along with altered bowel function.The underlying mechanisms of IBS remain unclear.Several studies showed that the attack of IBS might be related to the gastrointestinal motility,visceral hypersensitivity,infection of the bowel and several other factors.Existing animal models can be divided into 2 broad categories based on their primary pathogenetic mechanisms: those initiated by a central nervous system-directed(psychosocial) stressor and those stems from a gut-directed stressor(gut inflammation,infection).This article reviews the current research of IBS animal model.
ABSTRACT
Objective To investigate the effect of 5-hydroxytryptamine(5-HT) and the plasticity of 5-HT3 and 5-HT4 receptors in the myenteric plexus on the pathogenesis of irritable bowel syndrome(IBS) subgroups.Methods Twenty-seven male rats were randomly divided into three groups: IBS with diarrhea(IBS-D) group,IBS with constipation(IBS-C) group and blank control group.IBS-D model was made in rats by intracolonic instillation with acetic acid.IBS-C model was made in rats by gastric instillation with cool water.After rats in each group were killed,a colon segment was removed for detecting enteric neuron and excitatory neurotransmitter in the myenteric plexus using 5-HT and 5-HT3,5-HT4 receptors immunohistochemistry method.Results ① The number of 5-HT positive neurons in the myenteric plexus of IBS-D group(4.37?0.88) group was significantly higher than that in control group(2.99?0.41,P0.05).② The results of the experiment showed that there was no difference in the number of 5-HT3 receptor positive neurons in the myenteric plexus among each group(F=0.082,P=0.922).③ The positive value of 5-HT4 receptor immunoreactive neurons in the myenteric plexus of IBS-D group(141.98?6.96) group was significantly higher than that in control group(159.90?2.55)(P0.05).Conclusion Increased number of 5-HT and 5-HT4 receptor positive neurons in the myenteric plexus may be related to the pathogenesis of IBS-D rat model.